About Evrysdi tablets
The only oral, non-invasive spinal muscular atrophy (SMA) treatment also comes in tablet form
Evrysdi tablets have the same demonstrated results and safety as the liquid form.
Why Evrysdi tablets may be the right choice for you
Stored at room temperature†
Whether at work or on vacation, you can travel with Evrysdi tablets without the need for a cooler bag
Made to fit your lifestyle
You can choose to swallow the tablet whole with water or as a mixture with non-chlorinated drinking water (eg, filtered water, bottled water)—whichever works best for you
No need for measuring
Each once-daily Evrysdi tablet already contains your dose
†68°F to 77°F (20°C to 25°C).
Your experience with SMA might be different from others—that’s why having options in how you choose to take Evrysdi is important. Ask your doctor if Evrysdi tablets are right for you
How to take Evrysdi tablets
Evrysdi tablets can be swallowed whole with water
OR
Evrysdi tablets can be taken as a mixture with bottled water
- Keep room temperature bottled water on hand if you want to prepare Evrysdi as a mixture. Don’t mix it with any other liquid than bottled water*
- Please read the full Patient Information and Prescribing Information that come with your prescription before taking Evrysdi tablets for the first time
- Watch the video below to learn more about taking Evrysdi tablets
Learn more about obtaining, storing, and taking Evrysdi tablets
Evrysdi presents: Instructions for an SMA Treatment in Tablet Form. If you are starting treatment with Evrysdi, welcome. You're part of a large community of people who together with our doctors have chosen the only oral, non-invasive treatment option for SMA. Before we get started, I would like to review some Important Safety Information with you.
Now that we've got that covered, let's get started. Evrysdi comes in liquid and five milligram tablet form. They are both strawberry flavored. This video covers the steps involved for taking the tablet only. Evrysdi is delivered directly to your door each month. A specialty pharmacy will work with you to schedule a delivery. The package you receive includes a bottle that holds a 30-day supply of your medication. Check the expiration date and the product for damage before use. Do not use the treatment if it is expired or damaged. When taking the tablet, you just need to take one per day to help treat SMA. Evrysdi tablets can be stored at room temperature, so you have more freedom how and where you take them. It's important to keep the tablets in the bottle you receive them in. Evrysdi tablets are sensitive to moisture and the bottle they arrive in is designed to keep them dry. Remember to tightly secure the cab after each use. There are two ways to take Evrysdi tablets, let's get into those steps. You can swallow the tablet whole with water, or as a liquid, by mixing it in one teaspoon of room temperature bottled water. The tablet mixture cannot be taken using a gastrostomy or nasogastric tube. Press down and twist the cap to open the bottle. Once open, remove one tablet from the bottle. If swallowing the tablet whole, use water to take your dose. Do not take Evrysdi with any other liquid besides water. H2O is the way to go. If mixing the tablet, the liquid you should be using is room temperature bottled water. Tap water has different chlorine levels than bottled water and is not recommended. You'll also need a small, clean empty cup to get started. Pour one teaspoon or five milliliters of room temperature bottled water into your cup. Next, add a tablet and gently swirl the mixture in the cup. This can take up to three minutes. It's normal for the solution to look a little cloudy. Remember to keep the Evrysdi mixture out of sunlight. Drink the mixture right away, if it sits longer than 10 minutes, you'll need to throw it out and start over. To make sure you're also taking any leftover medication in the cup, add one more splash of room temp bottled water, at least one tablespoon or 15 milliliters. Gently swirl the cup once more and drink the remaining mixture right away. Now you're ready to make Evrysdi part of your routine, just like me. My name is Jim. I'm a father and professional voice-over artist and I've been taking Evrysdi since 2020. Now just a few important notes before we say goodbye. These are important people, focus up.
Your doctor, pharmacist, or nurse will show you how to prepare and take Evrysdi tablets. Always take Evrysdi tablets exactly as your healthcare provider tells you. Do not take or give this medicine until you have been shown how to properly prepare and take or give Evrysdi. Do not take an extra dose if you vomit at any time after taking Evrysdi. Store Evrysdi tablets at room temperature, 68°F to 77°F (20°C to 25°C). Do not take or give Evrysdi if it has been exposed to temperatures above 86°F (30°C). Keep the bottle tightly closed in order to protect from moisture. Keep Evrysdi and all medications out of the sight and reach of children. Do not get the Evrysdi tablet mixture on your skin or in your eyes. If the Evrysdi tablet mixture gets on your skin, wash the area with soap and water. If the mixture gets in your eyes rinse your eyes with water. If you spill the Evrysdi tablet mixture, dry the area with a dry paper towel and then clean with soap and water. Throw away the paper towel in the trash and wash your hands with soap and water. If you miss a dose, take it as soon as possible, but no more than six hours after the usual dosing time. If six hours have passed, just wait until the regularly scheduled time the next day. If you have questions about proper disposal, please visit the FDA drug disposal website.
Looking for some additional help? Evrysdi partnership and access liaisons are here. We call them PALs for short and that's fitting because they've got your back on treatment questions and more. Your PAL can help you explore financial support, plan for travel with Evrysdi and point you in the right direction if you're not sure who to call, and connect you to useful resources. If you haven't connected with a PAL yet, you can find the name and contact information for your local PAL at Evrysdi.com/PAL.
Storing Evrysdi: Flexibility that fits your lifestyle
No need to plan your day around treatment. Whether you’re at home or on the go, you can store Evrysdi tablets wherever it’s convenient for you, such as in a cabinet or in your bag.
- Evrysdi tablets should be kept at room temperature, 68°F to 77°F (20°C to 25°C)
- The tablets are sensitive to moisture, so don’t transfer them to a pill organizer. Keep them in the bottle they came in and remember to close it tightly
Tips for starting treatment
Request helpful tools and resources
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Información de prescripción de Evrysdi® (risdiplam). Genentech, Inc.
Información de prescripción de Evrysdi® (risdiplam). Genentech, Inc.
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Atrophy
The medical term for getting smaller, which is generally what happens to muscles when they are not stimulated by nerve cells.
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BSID-III
Stands for the Bayley Scales of Infant and Toddler Development–Third Edition, which is a tool used to assess a range of physical abilities, such as sitting, rolling, and crawling.
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CI
Stands for confidence interval, which shows how much a clinical result is likely to vary.
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DMT
Stands for disease-modifying treatment, which in the case of SMA, stimulates production of SMN2 protein.
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FDA
Stands for Food and Drug Administration.
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G-tube
Stands for gastrostomy tube, which is a tube inserted through the belly that brings nutrition directly to the stomach.
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Gene
The basic unit of heredity passed from parent to child, made up of sequences of DNA (deoxyribonucleic acid). They contain information that leads to the development of physical traits such as hair color.
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GI system
Stands for gastrointestinal system, also called the digestive system, which refers to the group of organs that take in food and liquids and break them down into energy the body can use.
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HINE-2
Stands for Hammersmith Infant Neurological Examination–Module 2, which is a tool used to assess 8 developmental milestones for infants, including head control, sitting, voluntary grasp, ability to kick, rolling, crawling, standing, and walking.
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Investigational
Term used to describe medical treatments that are currently being studied in clinical trials to determine how well they work and how safe they are to take.
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Larynx
Also known as the voice box, is a hollow tube in the middle of the neck, above the windpipe and esophagus. The larynx allows you to breathe and make sounds.
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MFM-32
Stands for Motor Function Measure-32 Items, which is a tool designed to capture changes in head, trunk, and limb motor movements using 32 elements in a broad range of people, including those who cannot walk. It uses 3 main categories: standing/transfer movements, upper/lower body movements, and hand/foot movements.
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Molecule
The smallest particle of a substance, made up of one or more atoms.
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NG-tube
Stands for nasogastric tube, which is a thin, soft tube that goes in through the nose, down the throat, and into the stomach to provide nutrition or medicine to those who cannot consume by mouth.
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Non-invasive
Term used to describe medicines or medical procedures that do not require inserting anything (such as a needle) through the skin or into a body opening.
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Oral
Refers to anything having to do with the mouth.
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PAL
Stands for Partnership and Access Liaison.
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Presymptomatic
When someone has not yet displayed any symptoms but may have underlying presence of the disease, as shown through testing or other means.
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Previously treated
When someone has taken either an approved or investigational medication specifically for SMA in the past.
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Progression
When the symptoms of SMA get worse over time.
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Progressive disease
Any condition that gets worse over time instead of improving.
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Protein
Large, complex molecules that play many important roles in the body, including making up the structure of cells and ensuring proper function of tissues and organs.
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RULM
Stands for Revised Upper Limb Module, which is a tool specifically designed for people 2.5 years and older living with SMA to evaluate strength in arm movements and the ability to perform certain tasks. It includes tests, such as picking up objects, like coins/tokens, tearing paper, raising a cup to the mouth, and opening a plastic container.
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Scoliosis
A sideways curve of the spine. Instead of appearing straight, the spine of a person with scoliosis will have an abnormal S or C shape that leads to their hips or shoulders appearing uneven.
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Sedation
A state of calmness, relaxation, or sleepiness as a result of medications called sedatives. Sedation can be used to help you relax or fall asleep for a medical procedure.
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SMA
Stands for spinal muscular atrophy, which is a genetic disease affecting the central nervous system, peripheral nervous system, and voluntary muscle movement.
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SMN
Stands for survival motor neuron, which is a type of protein that your muscles need to function.
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Spinal cord
A tube of tissue that runs from your brain down to your lower back and acts as an important part of your nervous system. The spinal cord carries nerve signals from your brain to the rest of your body, which allow you to feel sensations such as pressure or pain.
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Type 1 SMA
SMA symptoms that are present at 6 months of age or earlier. This is sometimes called “infantile onset.” Type 1 SMA is characterized by generalized muscle weakness, a weak cry, and muscle distress, often accompanied by failure to meet developmental milestones such as sitting up unassisted.
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Type 2 SMA
SMA symptoms that appear between the ages of 6 to 18 months. People with Type 2 SMA cannot stand or walk without help, but they can sit without support.
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Type 3 SMA
SMA symptoms that appear after 18 months of age. People with Type 3 SMA can walk independently but may have difficulty doing so or performing other movements such as running, rising from a chair, or climbing stairs.