US Healthcare Professionals

Evrysdi is designed to address the underlying cause of SMA

Evrysdi is designed to address the underlying cause of SMA

People with spinal muscular atrophy (SMA) have low levels of an important protein

Missing SMN icon

SMA is a genetic condition that causes muscles throughout the body to break down.

This happens when the body can’t produce enough of a key protein called “survival motor neuron,” or SMN, which is needed for specialized nerves called motor neurons to function properly.

Missing SMN icon

SMA is a genetic condition that causes muscles throughout the body to break down.

This happens when the body can’t produce enough of a key protein called “survival motor neuron,” or SMN, which is needed for specialized nerves called motor neurons to function properly.

Evrysdi is designed to help the body make more SMN protein

Within 4 weeks of treatment with Evrysdi, SMN protein levels in the blood more than doubled, and they were maintained for Types 1, 2, and 3 SMA throughout 2 years of the pivotal studies*

Increased SMN icon
SMN doubled icon


When studied in animals, this protein was distributed throughout the body.

*No data available in presymptomatic SMA (under 2 months).

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See Evrysdi in action
For adults and children
For infants
For presymptomatic SMA
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Important Safety Information and Indication

What is Evrysdi?

Evrysdi is a prescription medicine used to treat spinal muscular atrophy (SMA) in children and adults.

  • Before taking Evrysdi, tell your healthcare provider about all of your medical conditions, including if you:
    • are pregnant or plan to become pregnant, as Evrysdi may harm your unborn baby. Ask your healthcare provider for advice before taking this medicine
    • are a woman who can become pregnant:
      • Before you start your treatment with Evrysdi, your healthcare provider may test you for pregnancy
      • Talk to your healthcare provider about birth control methods that may be right for you. Use birth control while on treatment and for at least 1 month after stopping Evrysdi
      • Pregnancy Registry. Talk to your healthcare provider right away if you become pregnant while taking Evrysdi. Ask about registering with the Evrysdi Pregnancy Registry, which was created to collect information about your health and your baby's health. Your healthcare provider can enroll you in this registry by calling 1-833-760-1098 or visiting www.evrysdipregnancyregistry.com
    • are an adult male. Evrysdi may affect a man’s ability to have children (fertility). Ask a healthcare provider for advice before taking this medicine
    • are breastfeeding or plan to breastfeed. It is not known if Evrysdi passes into breast milk and may harm your baby
  • Tell your healthcare provider about all the medicines you take
  • You should receive Evrysdi from the pharmacy as a liquid. If the medicine in the bottle is a powder, do not use it. Contact your pharmacist for a replacement
  • Avoid getting Evrysdi on your skin or in your eyes. If Evrysdi gets on your skin, wash the area with soap and water. If Evrysdi gets in your eyes, rinse your eyes with water
  • The most common side effects of Evrysdi include:
    • For later-onset SMA:
      • fever
      • diarrhea
      • rash
    • For infantile-onset SMA:            
      • fever
      • diarrhea
      • rash
      • runny nose, sneezing, and sore throat (upper respiratory infection)
      • lung infection (lower respiratory infection)
      • constipation
      • vomiting
      • cough

These are not all of the possible side effects of Evrysdi. For more information on the risk and benefits profile of Evrysdi, ask your healthcare provider or pharmacist.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

Please see full Prescribing Information for additional Important Safety Information.

    • Información de prescripción de Evrysdi® (risdiplam). Genentech, Inc.

      Información de prescripción de Evrysdi® (risdiplam). Genentech, Inc.