US Healthcare Professionals

Treatment matters

Treatment matters

The progression of SMA is relentless – even if you don’t notice the impact day to day

Spinal muscular atrophy (SMA) is caused by a shortage of the survival motor neuron (SMN) protein, which your muscles need to function. As a result, muscles throughout your body continuously weaken.

This may lead to:

Spinal muscular atrophy (SMA) may cause swallowing difficulties over time

difficulty swallowing

Spinal muscular atrophy (SMA) may cause eating difficulties over time

difficulty eating

Spinal muscular atrophy (SMA) may cause loss of motor function over time

loss of motor function (for example, losing the ability to walk)

Spinal muscular atrophy (SMA) may cause respiratory complications over time

challenges breathing


Over time, it may cause complications with your bones, joints, and spine.

These changes happen whether you have Type 1, 2, or 3 SMA, even if you don’t notice it. For many, the subtle changes that happen from one day to the next can be hard to see until a key ability is lost.
These changes happen whether you have Type 1, 2, or 3 SMA, even if you don’t notice it. For many, the subtle changes that happen from one day to the next can be hard to see until a key ability is lost.


Small changes can have a big impact over time

“There were no treatments for SMA until I was an adult. It wasn’t until I started to lose my hand strength that I decided to ask my doctor about treatment.”

Christa, artist, mentor, and social butterfly, living with Type 2 SMA
Christa, living with Type 2 SMA
Keith, living with Type 3 SMA

“SMA can be subtle. Changes in strength can be gradual and hard to notice. You don’t know when, or what, or to what degree... but it’s relentless.”

Keith, gardener, lifelong learner, and language lover, living with Type 3 SMA

Treatment matters

Disease-modifying treatments have proven benefit across a broad range of ages and can help change the natural history of the disease.

These SMA treatments may:
  • Increase SMN protein
  • Help slow disease progression
  • Help maintain or improve motor function
  • Fit into your routine
     

Treatment can make a difference

You have the power to take action

“My biggest encouragement to others with SMA is to seek out treatment. Talk to your doctor. It can give you hope."

Dan, sit-up comic, motivational speaker, and sports fan, living with Type 2 SMA 
Dan, living with Type 2 SMA
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Make a choice today that could impact your future. Get to know Evrysdi: an at-home oral treatment with proven results in adults, children, and infants with SMA.

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What is Evrysdi?

Evrysdi is a prescription medicine used to treat spinal muscular atrophy (SMA) in children and adults.

  • Before taking Evrysdi, tell your healthcare provider about all of your medical conditions, including if you:
    • are pregnant or plan to become pregnant, as Evrysdi may harm your unborn baby. Ask your healthcare provider for advice before taking this medicine
    • are a woman who can become pregnant:
      • Before you start your treatment with Evrysdi, your healthcare provider may test you for pregnancy
      • Talk to your healthcare provider about birth control methods that may be right for you. Use birth control while on treatment and for at least 1 month after stopping Evrysdi
      • Pregnancy Registry. Talk to your healthcare provider right away if you become pregnant while taking Evrysdi. Ask about registering with the Evrysdi Pregnancy Registry, which was created to collect information about your health and your baby's health. Your healthcare provider can enroll you in this registry by calling 1-833-760-1098 or visiting www.evrysdipregnancyregistry.com
    • are an adult male. Evrysdi may affect a man’s ability to have children (fertility). Ask a healthcare provider for advice before taking this medicine
    • are breastfeeding or plan to breastfeed. It is not known if Evrysdi passes into breast milk and may harm your baby
  • Tell your healthcare provider about all the medicines you take
  • You should receive Evrysdi from the pharmacy as a liquid. If the medicine in the bottle is a powder, do not use it. Contact your pharmacist for a replacement
  • Avoid getting Evrysdi on your skin or in your eyes. If Evrysdi gets on your skin, wash the area with soap and water. If Evrysdi gets in your eyes, rinse your eyes with water
  • The most common side effects of Evrysdi include:
    • For later-onset SMA:
      • fever
      • diarrhea
      • rash
    • For infantile-onset SMA:            
      • fever
      • diarrhea
      • rash
      • runny nose, sneezing, and sore throat (upper respiratory infection)
      • lung infection (lower respiratory infection)
      • constipation
      • vomiting
      • cough

These are not all of the possible side effects of Evrysdi. For more information on the risk and benefits profile of Evrysdi, ask your healthcare provider or pharmacist.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

Please see full Prescribing Information for additional Important Safety Information.

    • Información de prescripción de Evrysdi® (risdiplam). Genentech, Inc.

      Información de prescripción de Evrysdi® (risdiplam). Genentech, Inc.